The Wavefront Aberrations of the Human Eye

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Our lab became involved in measuring the optics of the eye when we asked the question "Why do cones point towards a location that is not in the center of the pupil".   To answer this we improved a spatially resolved refractometer that Rob Webb and Murray Penned had built in the early 1990's when working on customized corneal surgery.  Using this technique we were able to investigate a range of phenomena, including how optical quality changes with age, how optical imperfections (waverfront aberrations) are a two edged sword, providing resistance to out of focus and chromatic image degradation, but also reducing the optimal image quality.

• Marcos, S, Burns,  S.A., Moreno-Barriuso, E, and Navarro, R "A new approach to the study of ocular chromatic aberrations" Vision Research 39, 4309-4324, 1999.
• He, JC, Burns,  S.A., and Marcos, S. “Monochromatic Aberrations in the Accommodated Human Eye” Vision Research 40, 41-48, 2000.
•  Marcos, S, Burns, S.A. "On the symmetry between eyes of wavefront aberration and cone directionality", Vision Research 40, 2437- 2447, 2000
• Moreno-Barriuso E, Marcos, S, Navarro, R, Burns SA “Comparing Laser Ray Tracing, Spatially Resolved Refractometer And Hartmann-Shack Sensor To Measure The Ocular Wave Aberration” Optometry and Visual Science 78,152 – 156, 2001.
• McLellan JS, Marcos S, and Burns SA “Age-related changes in monochromatic wave aberrations of the humage eye” Investigative Ophthalmology and Visual Science 42, 1390-1403, 2001, 
• Marcos S, Burns, SA, Prieto, P, Navarro, RN, Baraibar, B Investigating The Sources For Monochromatic Aberrations And Transverse Chromatic Aberration In Human Eyes Vision Research 41 (28) 3861-3871, 2001.
• Moreno-Barriuso E, Marcos, S, Navarro, R, Burns SA “Comparing Laser Ray Tracing, Spatially Resolved Refractometer And Hartmann-Shack Sensor To Measure The Ocular Wave Aberration” Optometry and Visual Science 78,152 – 156, 2001.
• McLellan JS, Marcos S, and Burns SA “Age-related changes in monochromatic wave aberrations of the humage eye” Investigative Ophthalmology and Visual Science 42, 1390-1403, 2001, 
• Marcos S, Burns, SA, Prieto, P, Navarro, RN, Baraibar, B Investigating The Sources For Monochromatic Aberrations And Transverse Chromatic Aberration In Human Eyes Vision Research 41 (28) 3861-3871, 2001
• Thompson, K.P., Staver, P.R., Garcia, JR, Burns, SA, Webb, RH, and Stulting, RD. Using InterWave® Aberrometry to Measure and Improve the Quality of Vision in LASIK Surgery. American Journal of Ophthalmology, Ophthalmology 111(7): 1368-1379, 2004, PMCID: PMC1458373.
• J. S. McLellan, P. M. Prieto, S. Marcos and S. A. Burns, Effects of interactions among wave aberrations on optical image quality, Vision Research 46 (18), 3009, 2006 PMCID: PMC2923468.
• Llorente, L, Marcos, S, Dorronsoro C, Burns SA, “The effect of sampling on real ocular aberration measurements” Journal of the Optical Society of America a-Optics Image Science and Vision, 24 (5), 2784-2796, 2007, PMCID: PMC2483833 
•  Benedi-Garcia, C, Vinas M, Dorronsoro C, Burns, SA Peli, E, Marcos S “Vision is protected against blue defocus” Scientific Reports, (2021), 11, 352 (2021). https://doi.org/10.1038/s41598-020-79911-w PMID: 33432060 PMCID: PMC7801416