Nonlinear analysis of the electroretinogram

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ERG

To investigate the early steps in visual processing we turned to the flicker ERG.   We showed that the retina can respond to flicker well about 150 Hz (large fields) and that the nonlinear response components went much higher in frequency.  We analyzed the ERG using a two-sine wave technique where the presence of a nonlinear response component would cause responses at the sum and difference frequencies.  Thus, we could measure the early filter response of the retina, which showed very little light adaption, as well as how and where cones converged their inputs.

Publications

  • Burns SA, Kreitz M, and Elsner AE "Apparatus Note: A computer controlled, two color, laser-based optical stimulator for vision research". Applied Optics 30: 2063-2065, 1991.
  • Burns SA, Elsner AE, and Kreitz M "Analysis of Nonlinearities in the Flicker ERG", J. Optom. Vis. Sci. 69, 95-102, 1992
  • Chang, Y., Burns, SA, and Kreitz, MR, "Red-Green Flicker Photometry and Nonlinearities in the Flicker ERG". J. Opt. Soc. Amer. 10, 1413-1422, 1993.
  •  Wu, S, Burns, SA and Elsner, AE. "Effects of Flicker Adaptation and Temporal Gain Control in the Flicker ERG. Vision Research 35, 2943-2953, 1995        
  • Burns, SA, and Elsner, AE. The Response of the Retina at Low Temporal Frequencies. Journal of the Optical Society of AmericaA. 13, 667-672, 1996.
  • Wu, S. and Burns, SA. Analysis of retinal light adaptation with the flicker electroretinogram. Journal of the Optical Society of America A. 13, 649-657, 1996. 
  • Wu, S, Burns, SA, Reeves, A. and Elsner AE. "Flicker Brightness Enhancement and Visual Nonlinearity" Vision Research 36, 1573-1582,1996.
  • Wu, S, Burns, SA, Elsner, AE, Eskew, RT, and He, J. “Rapid sensitivity changes on flickering backgrounds: tests of models of light adaptation”, J. Optical Soc. Amer 14, 2367-2378, 1997.