Managing the AO Imaging

Controlling AO and Relating the results to clinical imaging modalities

Our original controls was developed by Remy Tumbar and Dan Sumorok. The control was a versatile system for the time, incorporating multiple approaches to centroiding and incorporating regularization. Weiyao Zou added capabilities two mirror woofer tweeter system and later Alberto de Castro improved the ability to work with difficulty eyes.

Improving the clinical utility of AO.

Lucie Sawides added direct mapping of steerable imaging onto the Heidelberg Spectralis (tm). Ting Luo as part of her thesis has added fully automated montaging of retinal images and I am working on building annotation layers into these montages to better automatically document measurements.

Relevant Papers

Webb, RH, Albanese, MJ, Zhou, Y, Bifano, T and Burns, SA “A stroke amplifier for deformable mirrors” Applied Optics 43(28), 5330-5333 , 2004, PMID: 15495423
Burns, S.A., Tumbar, R., Elsner, A.E., Ferguson, D., & Hammer, D.X.. Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope. Journal of the Optical Society of Americaa-Optics Image Science and Vision, 24 (5), 1313-1326., 2007, PMCID: PMC2443858
Zou, W, Qi, X, Burns, SA, “Wavefront aberration sorting and correction for dual-deformable-mirror adaptive optics system” Optics Letters, Vol. 33, Issue 22, pp. 2602-2604, 2008 PMCID: PMC2738988
Zou, W, Burns, SA, "High-accuracy wavefront control for retinal imaging with Adaptive-Influence-Matrix Adaptive Optics" Optics Express. Vol. 17 Issue 22, pp.20167-20177 (2009), PMCID: PMC2882182
Zou, W, Qi, X, Burns, SA, “Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm”, Biomedical Optics Express, Vol. 2, Issue 7, pp. 1986-2004 doi:10.1364/BOE.2.001986. (2011) PMID: 21750774 PMCID: PMC3130583
Huang, G, Zhong, Z, Zou W, Burns, SA “Lucky Averaging: Quality improvement on Adaptive Optics Scanning Laser Ophthalmoscope Images” Optics Letters, Vol. 36, No. 19 3786-3789 (2011). PMCID: PMC3407537
Zou, W, Qi, X, Huang, G, Burns, SA, Improving wavefront boundary condition for in vivohigh resolution adaptive optics ophthalmic imaging, Biomedical Optics Express. Vol. 2, Issue 12, pp. 3309-3320 (2011) PMID: 22162821 PMCID: PMC3233250
Zou W, Burns SA. Testing of Lagrange multiplier damped least-squares control algorithm for woofer-tweeter adaptive optics. Appl Opt. 2012 Mar 20;51(9):1198-208. doi: 10.1364/AO.51.001198. PMID: 2441462. PMCID: PMC3407539
Chui, T. Y. P., D. A. VanNasdale and S. A. Burns (2012). "The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope." Biomed. Opt. Express 3(10): 2537-2549. PMID: 23082294 PMCID: PMC3470005
de Castro Alberto, Huang Gang, Sawides, Lucie, Luo, Ting, Burns, Stephen A., Rapid high resolution imaging with a dual-channel scanning technique, Optics Letters: 2016 41(8) 1881-1884 PMID: 27082369 PMCID: PMC5535314
Marcos S; Werner JS; Merrigan WH; Burns, SA, Artal P; Atchison D; Hampson KM; Legras R; Lundstrom L; Yoon G; Carroll J; Choi SS; Doble N; Dubis AM; Dubra A; Elsner AE; Jonnal R; Miller DT; Paques M; Smithson HE; Young LK; Zhang Y; Campbell M; Hunter J; Metha A; Palczewska G; Schallek J; Sincich LC, Vision Science and Adaptive Optics, The State of the Field. 2017, 132: 3–33 https://doi.org/10.1016/j.visres.2017.01.006PMID: 28212982PMCID: PMC5437977
de Castro A, Sawides, L. Qi, X, Burns, SA, Adaptive Optics Retinal Imaging with Automatic Detection of the Pupil and its Boundary in Real time using Shack Hartmann Images, 2017, Applied Optics 2017, 56, 6748-6754 https://doi.org/10.1364/AO.56.006748 PMID: 29048013 PMCID: PMC5973534

Stephen A. Burns, Indiana University, Vision Science Lab

Managing the AO Imaging

Controlling AO and Relating the results to clinical imaging modalities

Relevant Papers

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Managing the imaging