Adaptive Optics Systems

In recent years the Burns group has developed four different adaptive optics systems. These include one capable of performing real-time polarimetric imaging of the human retina ; one optimized for small clinical instrumentation, developed in collaboration with Boston Micromachines Corp., and now being deployed at Joslin Diabetes Center; our main system which uses dual deformable mirrors to allow imaging individuals with large refractive errors over a large field of view; and a new system that allows precise measurement of blood velocity as well as using programmable apertures using DLP technology. This system, by having a final stage of the optics which provides almost 30 degrees of view of the retina, allows us to use clinical images taken with traditional low resolution devices such as the Heidelberg Spectralis, and quickly deploy our high resolution images to the regions of most interest.

Some have asked for more information on our system so I put in two files in the download section below. One is from the Frontiers in Optics meeting, 2017, which is an eposter in powerpoint (EPOsterFIO_2017.pptx). Simply start the slideshow and then click on interesting topics. The other is an SPIE paper ( Burns_Adaptive Optics Systems for Vision Science_Paper_1_1_2018 ).

References

Basic System

Burns, SA, Marcos, S, Elsner, AE, Bara, S, “Contrast Improvement for Confocal Retinal Imaging Using Phase Correcting Plates” Optics Letters. 27: 400-402, 2002.
Hammer,DX, Ferguson, RD, Bigelow CD, Iftimia , NV, Ustun te, Burns, SA, "Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging", Opt. Express 14, 3354-3367 2006 PMC2923468
Burns, S.A., Tumbar, R., Elsner, A.E., Ferguson, D., & Hammer, D.X.. Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope. Journal of the Optical Society of Americaa-Optics Image Science and Vision, 24 (5), 1313-1326., 2007, PMCID: PMC2443858
Song, H, Zhao, Y, Chui, Y, Qi X, Burns, SA, Stokes Vector Analysis of Adaptive Optics Images of the Retina, Optics Letters, 33, 137-140, 2008, PMCID: PMC2710772
Ferguson, RD, Zhong, Z, Hammer, DX, Mujat, M, Patel, AH, Deng, C, Zou, W, Burns, SA, "Adaptive optics SLO with integrated wide-field retinal imaging and tracking" J. Opt. Soc. Am. A 27, A265-A277 (2010). PMCID: PMC3071649
de Castro Alberto, Huang Gang, Sawides, Lucie, Luo, Ting, Burns, Stephen A., Rapid high resolution imaging with a dual-channel scanning technique, Optics Letters: 2016 41(8) 1881-1884 PMID: 27082369 PMCID: PMC5535314
Sapoznik, KA, Luo, T, de Castro, A, Sawides, L, Warner RL, Burns, SA. “Enhanced retinal vasculature imaging with a rapidly configurable aperture”, 2018, Biomedical Optics Express. Vol. 9, Issue 3, pp. 1323-1333 https://doi.org/10.1364/BOE.9.001323PMID: 29541524 PMC5846534
Burns, SA, Elsner, AE, Sapoznik, KR, Warner, RL, Gast, TJ, “Adaptive Optics Imaging of the Human Retina”, 2019; Progress in Retinal and Eye Research, Volume 68, January 2019, Pages 1-30 PMC6347528 https://doi.org/10.1016/j.preteyeres.2018.08.002 PMID: 30165239 PMC6347528
Akondi,V Kowalski BJ, Burns, SA, and Dubra, A. “ Dynamic distortion in resonant galvanometric optical scanners” Optica 2020, Vol. 7, Issue 11, pp. 1506-1513 (2020) https://doi.org/10.1364/OPTICA.405187
Luo, T, Warner, RL, Walker, BR, Sapoznik, KR, Burns, SA, “Template free eye motion correction for scanning systems”, Optics Letters, Vol. 46, Issue 4,pp. 753-756 (2021) https://doi.org/10.1364/OL.415285 PMID: 33577506
Williams, DR, Burns, SA, Miller DR, Roorda A, “The Evolution of Adaptive Optics Retinal Imaging” Biomed Opt. Express 14, 1307-1338 (2023) https://doi.org/10.1364/BOE.485371
Luo, T, Gilbert, RN, Sapoznik, KA, Walker, BR, Burns, SA. Automatic montaging of adaptive optics retinal images based on graph theory Biomedical Optics Express (2024): ol. 15, pp. 1021-1037 (2024) https://doi.org/10.1364/BOE.505013

Stephen A. Burns, Indiana University, Vision Science Lab

Adaptive Optics Systems

References

Basic System

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